Cat. No.: 503 003
Amount: 50 µg
Price:
$375.00
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| Cat. No. 503 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to the N-terminal part of mouse NeuroD1 (UniProt Id: Q60867) |
| Reactivity |
Reacts with: mouse (Q60867), rat (Q64289). Other species not tested yet. |
| Remarks |
IHC: Antigen retrieval (citrate buffer pH 6) can be used to improve the signal in immunohistochemical staining. |
| Data sheet | 503_003.pdf |
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NeuroD1, also referred to as Neurogenic differentiation factor 1 or BETA2, is a member of the basic helix-loop-helix (bHLH) family of transcription factors. It forms heterodimers with other bHLH proteins and activates transcription of genes with E box-containing promoters. It is expressed in the developing brain and pancreas as well as in differentiating neurons in both the central and peripheral nervous system (1, 2, 3).
NeuroD1 acts as a differentiation factor during neurogenesis (1, 4). It regulates the development of the mammalian retina, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus (1, 2, 3), endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine (5).
Mice lacking NeuroD1 become severely diabetic, show several developmental and functional defects throughout the body, and die shortly after birth (1,2,5).
Human mutations have been linked to a number of types of diabetes, including type I diabetes mellitus and maturity-onset diabetes of the young (1).